VDR is a gene which encodes for a protein that functions as a receptor for vitamin D, which regulates bone development and calcium absorption. A variant of the gene called the rs2228570 (FokI polymorphism) is associated with lower bone mineral density in white prepubertal girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated through the reciprocal pattern and the temporal occupancy of the VDRE between the two components. It is also modulated by chromosomal location and binding preferences data room service provider for certain hormones. Microarray studies of human cells show that more than 100 genes have VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository for data and documents relevant to legal, business transactions or proceedings with restrictions on viewing, downloading or printing. It utilizes central servers and an extranet connection that is an Internet connection that has restricted access, to provide restricted access to log-in for specific times at which users can browse the documents and data.
VDRs are used most often by investment banks and companies involved in mergers and acquisitions. They must be able to share information in a transparent manner with potential investors and buyers. Due diligence can also require a large amount of data. Life science companies also utilize VDRs to store everything from clinical trials results to HIPAA documentation.